Unrepaired ASD for cemented hip hemiarthroplasty83-year-old woman, 58 kg, for cemented hemiarthroplasty of a displaced femoral neck fracture
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Know this first
- Anything that raises PVR can reverse her shunt to right-to-left.
- Cement can cause hypotension, hypoxia, raised PVR, RV failure and arrest.
- Apixaban needs at least 72 hours off before a neuraxial block.
- After major surgery, stroke thrombolysis is weighed case by case rather than ruled out.
The patient
The examiner asks
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Consider
What are your concerns?
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- An 83-year-old with an unrepaired ASD and AF on apixaban, for urgent cemented hemiarthroplasty. Patient
- At 83 with a broken hip, her delirium risk is high; I screen cognition before any sedation.
- Today her flow is left to right; anything that raises PVR can reverse it. Disease
- Once reversed, air, fat or cement debris can cross to her brain.
- A cemented stem risks bone cement implantation syndrome, which loads her right heart. Surgery
- Fixing her hip within 24 hours means less pain and a shorter stay.
Prepare
Take me through her risk assessment and preparation.
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- Urgency: hip fracture, best done within 24 hours; time to assess, not to delay. Stem trigger
- Active cardiac conditions? None: her AF is rate-controlled and she isn't in failure. Disease
- Risk score: none of the RCRI items, so RCRI 0.
- Functional capacity: can't be judged with a broken hip, and at RCRI 0 it changes nothing.
- Decision: proceed today without further cardiac testing.
- Apixaban 30 hours ago rules out a spinal; it needs 72 hours off.
- Every line de-aired with filters; cement technique agreed with the surgeon.
Plan
What is your anaesthetic plan?
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- General anaesthesia, arterial line placed before induction. Disease
- Reduced propofol for her age; above 1.5 mg/kg causes severe hypotension in older adults.
- No hypoxia, hypercarbia or acidosis, so her PVR stays down.
- Surgeon lavages and vents the canal and warns me before cementing; uncemented if feasible. Surgery
- At cementing: FiO2 up, pressure topped up, adrenaline drawn up. Crisis
- HDU after; apixaban restarts once the surgeon is happy with haemostasis. After surgery
Crisis
As the cemented stem goes in, BP falls to 70/40, SpO2 to 82%, and ETCO2 drops. What do you do?
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- Bone cement implantation syndrome; her rising PVR may also be reversing her ASD shunt. (Crisis)
- Help called, surgeon told, FiO2 to 1.0.
- Phenylephrine 50–100 mcg, then adrenaline 0.05–0.2 mcg/kg/min to support her RV.
- Fluid to keep her filled, without overloading her dilated RV.
- Ventilation tuned against hypoxia, hypercarbia and acidosis; each pushes her PVR higher.
- If she loses her pulse: adult arrest algorithm, CPR, adrenaline 1 mg every 3–5 minutes.
Crisis
At the end she is slow to wake, with a new right hemiparesis. What do you do?
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- Paradoxical embolism across her ASD until proven otherwise: a perioperative stroke. Crisis
- Stroke team now, and emergent brain imaging.
- Surgery today is a relative bar to thrombolysis; clot retrieval if bleeding risk is high.
- Meanwhile oxygen, and her pressure held at her baseline.
- Stroke unit or ICU; when apixaban restarts is decided with neurology. After surgery
Fatal mistakes
- Air bubbles in her lines.
- Cementing with no warning, no monitoring and no pressor ready.
- Calling a paradoxical stroke slow emergence.
- A spinal 30 hours after apixaban.
Checked against: Miller 10e · Stoelting 8e · Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: ASRA Pain Medicine evidence-based guidelines (fifth edition) (2025) · SNACC consensus statement: perioperative care of patients at high risk for stroke during or after non-cardiac, non-neurologic surgery (2014)
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