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Unrepaired ASD for cemented hip hemiarthroplasty83-year-old woman, 58 kg, for cemented hemiarthroplasty of a displaced femoral neck fracture

From memory: the diagnosis and the notes are hidden. Answer each question aloud, then press Show.

Know this first

  • Anything that raises PVR can reverse her shunt to right-to-left.
  • Cement can cause hypotension, hypoxia, raised PVR, RV failure and arrest.
  • Apixaban needs at least 72 hours off before a neuraxial block.
  • After major surgery, stroke thrombolysis is weighed case by case rather than ruled out.

The patient

83-year-old woman, 58 kg, for cemented hemiarthroplasty of a displaced femoral neck fracture, listed for today. Secundum ASD, never closed, shunting left to right; dilated right heart; PA systolic 42 mmHg on last year's echo; paroxysmal AF. Drugs: apixaban (last dose 30 hours ago), bisoprolol. Vitals: BP 136/74, HR 78 irregular, SpO2 94% on air, RR 18.

The examiner asks

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  1. Consider

    What are your concerns?

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    • An 83-year-old with an unrepaired ASD and AF on apixaban, for urgent cemented hemiarthroplasty. Patient
    • At 83 with a broken hip, her delirium risk is high; I screen cognition before any sedation.
    • Today her flow is left to right; anything that raises PVR can reverse it. Disease
    • Once reversed, air, fat or cement debris can cross to her brain.
    • A cemented stem risks bone cement implantation syndrome, which loads her right heart. Surgery
    • Fixing her hip within 24 hours means less pain and a shorter stay.
  2. Prepare

    Take me through her risk assessment and preparation.

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    • Urgency: hip fracture, best done within 24 hours; time to assess, not to delay. Stem trigger
    • Active cardiac conditions? None: her AF is rate-controlled and she isn't in failure. Disease
    • Risk score: none of the RCRI items, so RCRI 0.
    • Functional capacity: can't be judged with a broken hip, and at RCRI 0 it changes nothing.
    • Decision: proceed today without further cardiac testing.
    • Apixaban 30 hours ago rules out a spinal; it needs 72 hours off.
    • Every line de-aired with filters; cement technique agreed with the surgeon.
  3. Plan

    What is your anaesthetic plan?

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    • General anaesthesia, arterial line placed before induction. Disease
    • Reduced propofol for her age; above 1.5 mg/kg causes severe hypotension in older adults.
    • No hypoxia, hypercarbia or acidosis, so her PVR stays down.
    • Surgeon lavages and vents the canal and warns me before cementing; uncemented if feasible. Surgery
    • At cementing: FiO2 up, pressure topped up, adrenaline drawn up. Crisis
    • HDU after; apixaban restarts once the surgeon is happy with haemostasis. After surgery
  4. Crisis

    As the cemented stem goes in, BP falls to 70/40, SpO2 to 82%, and ETCO2 drops. What do you do?

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    • Bone cement implantation syndrome; her rising PVR may also be reversing her ASD shunt. (Crisis)
    • Help called, surgeon told, FiO2 to 1.0.
    • Phenylephrine 50–100 mcg, then adrenaline 0.05–0.2 mcg/kg/min to support her RV.
    • Fluid to keep her filled, without overloading her dilated RV.
    • Ventilation tuned against hypoxia, hypercarbia and acidosis; each pushes her PVR higher.
    • If she loses her pulse: adult arrest algorithm, CPR, adrenaline 1 mg every 3–5 minutes.
  5. Crisis

    At the end she is slow to wake, with a new right hemiparesis. What do you do?

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    • Paradoxical embolism across her ASD until proven otherwise: a perioperative stroke. Crisis
    • Stroke team now, and emergent brain imaging.
    • Surgery today is a relative bar to thrombolysis; clot retrieval if bleeding risk is high.
    • Meanwhile oxygen, and her pressure held at her baseline.
    • Stroke unit or ICU; when apixaban restarts is decided with neurology. After surgery

Fatal mistakes

  • Air bubbles in her lines.
  • Cementing with no warning, no monitoring and no pressor ready.
  • Calling a paradoxical stroke slow emergence.
  • A spinal 30 hours after apixaban.

Checked against: Miller 10e · Stoelting 8e · Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: ASRA Pain Medicine evidence-based guidelines (fifth edition) (2025) · SNACC consensus statement: perioperative care of patients at high risk for stroke during or after non-cardiac, non-neurologic surgery (2014)

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