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Bronchopleural fistula with empyema after lobectomy71-year-old man, 56 kg, three weeks after right lower lobectomy

From memory: the diagnosis and the notes are hidden. Answer each question aloud, then press Show.

Know this first

  • Three hazards: soiling the healthy lung, tension pneumothorax, and ventilation lost through the fistula.
  • Continuous bubbling in the drain means a large fistula.
  • Lung isolation is confirmed before positive pressure or turning.
  • A double-lumen tube allows suction and protects the healthy lung.

The patient

71-year-old man, 56 kg, three weeks after right lower lobectomy, for urgent rethoracotomy and fistula repair. Fever, purulent sputum, and a continuous air leak with pus through the right chest drain; weight loss of 7 kg. Drugs: IV antibiotics started yesterday; nil else regular. Vitals: BP 96/54, HR 116, SpO2 92% on 40% oxygen, RR 28, temperature 38.9°C.

The examiner asks

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  1. Consider

    What are your concerns?

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    • A 71-year-old with a bronchopleural fistula, empyema and sepsis, for urgent rethoracotomy and repair. Patient
    • At 71, septic and 7 kg lighter, he has little reserve; I record his baseline cognition for delirium.
    • Air leak, fever and pus after lobectomy point to a fistula. Disease
    • Three risks: pus soiling his left lung, tension pneumothorax, and breaths lost through the fistula.
    • His leak bubbles continuously, so the fistula is large.
  2. Prepare

    How do you prepare him?

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    • Sepsis first: antibiotics within the hour, cultures, and crystalloid at 30 mL/kg within three hours. Disease
    • Noradrenaline at 0.05–0.5 mcg/kg/min if he stays hypotensive after fluid; arterial line before induction.
    • His drain stays in and open; it protects him from tension pneumothorax under positive pressure.
    • No thoracic epidural while he's septic; paravertebral by the surgeon or systemic analgesia instead.
    • He sits up, leaning to the right, so pus stays in the infected side. Airway
  3. Plan

    How will you secure his airway?

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    • Lung isolation before any positive pressure or turning; that is the rule here. Airway
    • Left-sided double-lumen tube: it seals the healthy left lung away from the right stump.
    • Safest is awake fibreoptic placement, if he can cooperate with topical anaesthesia.
    • Otherwise a gas or titrated induction, keeping him breathing until the left lumen is sealed.
    • Bronchoscope confirms the tube position, then again after he is turned.
    • Small breaths at low airway pressure to the left lung once isolated. Disease
  4. Crisis

    During laryngoscopy he coughs up pus; SpO2 falls to 80%, BP 88/50. What do you do?

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    • Pus is soiling his left lung: stay head-up, suction the airway, 100% oxygen. Crisis
    • Place the left double-lumen tube now and inflate the bronchial cuff to seal the left lung.
    • Suction down the left lumen, then bronchoscopic toilet and position check.
    • Ventilate only the left lung, gently; the right lumen stays open to drain.
    • No turning until the left lung is clean and isolation is proven.
    • Expect pneumonitis in the left lung; ICU ventilation if his gas exchange stays poor. After surgery
  5. Crisis

    Once he is turned, the ventilator delivers 450 mL but only 150 mL returns; SpO2 85%. What do you do?

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    • Two thirds of each breath is leaving through the fistula: bronchoscope first to check the tube. Crisis
    • Turning can shift the tube; I reposition it so only the left lung is ventilated.
    • Small breaths and low pressures; I accept a higher CO2 rather than force the leak.
    • Never clamp his drain: a blocked drain turns this leak into a tension pneumothorax.
    • Still failing: high-frequency ventilation lowers peak pressure and may cut the fistula leak.
    • Extubate early after repair to spare the stump; otherwise ICU, then early extubation. After surgery

Fatal mistakes

  • Positive-pressure ventilation before the fistula side is isolated.
  • Clamping the chest drain.
  • Turning him with the healthy lung dependent before isolation.
  • Thoracic epidural in a septic patient.

Checked against: Miller 10e · Surviving Sepsis Campaign: international guidelines for sepsis and septic shock (2021)

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