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Obstetric

Sheet 05Anaesthesia

Obstetric

Labour analgesia, platelets before a neuraxial block, the caesarean anaesthetic, pre-eclampsia and magnesium, haemorrhage, and the airway that fails.

Cards
21
Minutes
about14
Scenarios
21

Start at card 1Review the rules

Core rulesRead these first3 cards · about 2 min

  1. 01The mother first
  2. 02Obstetric haemorrhage, in order
  3. 03Uterine blood flow and the placenta

The mother first

01 / 21

Resuscitate the mother and displace the uterus; no circulation by 4 minutes, deliver by 5.

Moment in the arrestAction
Starting chest compressions, open its explanationKeep her supine and displace the uterus by hand
First minutes of arrest, open its explanationManual uterine displacement; caesarean if circulation absent at 4 minutes
Shockable rhythm, open its explanationStandard shock energy, unchanged
Drugs during the arrest, open its explanationStandard advanced cardiac life support (ACLS) drugs, unchanged
No return of circulation by 4 minutes, open its explanationStart caesarean at the arrest site; deliver by 5 minutes
During and after the caesarean, open its explanationKeep resuscitating the mother throughout

Report a problem with card 1: The mother first

Obstetric haemorrhage, in order

02 / 21

Haemorrhage leads maternal death: massage, oxytocin, second uterotonic at dose, then red cells, plasma, fibrinogen.

The leading cause

SettingCommonest cause
Maternal death, worldwide, open its explanationObstetric haemorrhage
US data, heart disease grouped, open its explanationCardiovascular first; cardiomyopathy alone still below haemorrhage
Heavy postpartum bleeding, open its explanationUterine atony first; then trauma, retained tissue, clotting

Uterotonics, in order

StepDrug and dose
First step, open its explanationMassage uterus, oxytocin; before airway, surgery or escalation
Bleeding despite oxytocin: ergot alkaloid, open its explanationMethylergometrine 0.2 mg IM; not intravenous as routine
Bleeding despite oxytocin: prostaglandin, open its explanationCarboprost 0.25 mg IM q15–60 min, or misoprostol 600–800 mcg

Blood products

BleedGive
Large bleed on clinical signs, open its explanationStart red cells without waiting for labs
Massive obstetric haemorrhage, open its explanationRed cells and plasma about 1:1, early fibrinogen; then coagulation‑guided
Large bleed, placental abruption, open its explanationEarly fibrinogen, coagulation studies, prepare massive transfusion
Still bleeding after balanced transfusion, open its explanationCryoprecipitate with red cells
Recombinant factor VIIa, open its explanationNot recommended: off‑label, adverse events reported

Bleeding after caesarean

FindingAction
Bleeding with hypotension hours later, open its explanationReturn to theatre promptly; resuscitate en route, blood ready
Haemoglobin down, international normalised ratio (INR) up after crystalloid, open its explanationRed cells plus plasma, not more clear fluid; theatre

Report a problem with card 2: Obstetric haemorrhage, in order

Uterine blood flow and the placenta

03 / 21

Uterine flow has no autoregulation and follows maternal pressure and tone; only small lipophilic drugs cross.

Uterine blood flow, no autoregulation

DirectionCause
Rises, open its explanationFalling maternal sympathetic tone, as with effective epidural
Falls, open its explanationHypotension, contractions, caval compression, vasoconstriction

Fetal oxygen supply

Maternal stateEffect
Alkalaemia in labour, open its explanationLeft‑shifted maternal curve; less oxygen unloads to fetus

Placental transfer of drugs

DrugCrosses the placenta
Opioids, benzodiazepines, induction agents, open its explanationCross: small, lipid‑soluble, poorly ionised
All neuromuscular blockers, heparin, open its explanationBarely cross: charged
Ketamine–suxamethonium induction for caesarean, open its explanationUndepressed neonate, normal tone; suxamethonium barely crosses

Report a problem with card 3: Uterine blood flow and the placenta

Part 1 · DecisionsWhat to do5 cards · about 3 min

  1. 04Labour analgesia
  2. 05Platelets and bleeding disorders before neuraxial
  3. 06Planning the caesarean anaesthetic
  4. 07Surgery and drugs during pregnancy
  5. 08Drugs that contract or relax the uterus

Labour analgesia

04 / 21

Offer neuraxial unless she refuses; it lengthens the second stage, not the caesarean rate.

SituationDecision
Declines all analgesic drugs in labour, open its explanationSupport choice: water immersion and massage
Later accepts medication, open its explanationNeuraxial block remains most effective
Absolute contraindication to labour epidural, open its explanationPatient refusal; not late dilation, trial after caesarean, platelets 100,000
Epidural effect on second stage, open its explanationMay lengthen it; possibly more instrumental delivery
Epidural effect on caesarean rate, open its explanationNo increase; does not speed delivery
Opioid use disorder in labour, open its explanationOffer neuraxial; continue methadone or buprenorphine; no antagonist
Severe mitral stenosis in labour, open its explanationEarly, carefully titrated epidural unless coagulopathy
Suspected or confirmed COVID‑19 in labour, open its explanationPandemic advice: consider suspending nitrous; neuraxial, steroids, magnesium continue

Report a problem with card 4: Labour analgesia

Platelets and bleeding disorders before neuraxial

05 / 21

Judge the count and the disorder; no added test predicts an epidural haematoma.

Planning the caesarean anaesthetic

06 / 21

Choose the technique the airway and the blood allow; dose antibiotics by weight.

Choosing the technique

FindingDecision
Difficult airway, fetal distress, no epidural, open its explanationRapid spinal by most senior anaesthetist; general anaesthesia (GA) only awake
Platelets ≥70,000, open its explanationNeuraxial reasonable; haematoma risk likely low
Severe pre‑eclampsia with airway oedema, open its explanationPrepare difficult intubation; check platelets, bleeding signs before neuraxial

Antibiotic prophylaxis

Body weightCefazolin dose
120 kg or more, open its explanation3 g intravenously
Under 120 kg, e.g. 105 kg, open its explanation2 g, the standard dose

Report a problem with card 6: Planning the caesarean anaesthetic

Surgery and drugs during pregnancy

07 / 21

Operate when needed with a full-stomach induction; monitor the fetus when viable; paracetamol, never late non-steroidal anti-inflammatory drugs (NSAIDs).

Surgery in pregnancy

SituationDecision
Laparoscopy, any trimester, open its explanationDo not delay; keep carbon dioxide normal, monitor fetus
Fetal heart check around surgery (ACOG), open its explanationBefore/after: Doppler previable, electronic viable; intraoperative individualised
Symptomatic reflux beyond first trimester, general anaesthesia, open its explanationFull stomach: rapid‑sequence induction, cuffed tracheal tube
Cerebral bleed needing induction, open its explanationModified rapid sequence: lidocaine pretreatment, propofol, high‑dose rocuronium or suxamethonium

Analgesics in pregnancy

ChoiceIn pregnancy
Paracetamol versus NSAIDs, open its explanationParacetamol throughout; NSAIDs limited doses 20–30 weeks only
Ketorolac or indomethacin, third trimester, open its explanationAvoid from 30 weeks
NSAID fetal effect after 30 weeks, open its explanationPremature ductus arteriosus closure, not delayed closure

Report a problem with card 7: Surgery and drugs during pregnancy

Drugs that contract or relax the uterus

08 / 21

Match the uterotonic to the patient; volatiles and nitroglycerin relax the uterus.

Uterotonic by coexisting disease

DiseaseUterotonic to give or avoid
Asthma or pre‑eclampsia, open its explanationGive oxytocin as the uterotonic
Asthma, open its explanationAvoid carboprost: bronchospasm
Pre‑eclampsia, open its explanationAvoid methylergometrine: hypertension, vasospasm
Wheeze after a second uterotonic, asthma, open its explanationSuspect carboprost, a prostaglandin F2α analogue
Asthma, other uterotonics have failed, open its explanationCarboprost with caution, as last resort

Relaxing the uterus

NeedChoice
Anaesthetic that lowers uterine tone, open its explanationVolatile halogenated agent; higher concentration lowers it more
Anaesthetic leaving uterine tone unchanged, open its explanationNitrous oxide: no change in uterine activity
Breech second twin needs manipulation, open its explanationSmall IV nitroglycerin bolus, not general anaesthesia or oxytocin

Report a problem with card 8: Drugs that contract or relax the uterus

Part 2 · RecognitionWhat it is5 cards · about 4 min

  1. 09Normal pregnancy or not
  2. 10The fetal heart trace
  3. 11The hypertensive disorders
  4. 12Placenta accreta spectrum
  5. 13Nerve injury after delivery

Normal pregnancy or not

09 / 21

Know what pregnancy raises, lowers and leaves alone; a diastolic murmur it never explains.

What pregnancy raises at term

SystemRises
Breathing, open its explanationTidal volume, inspiratory reserve, minute ventilation
Breathing in labour, open its explanationPain raises minute ventilation further
Heart and blood, open its explanationCardiac output, stroke volume, heart rate, red cell mass
Clotting, open its explanationFibrinogen; factors VII, VIII, IX, X, XII

What pregnancy lowers at term

SystemFalls
Lung volumes, open its explanationExpiratory reserve volume (ERV), residual volume, functional residual capacity (FRC)
Blood gas, open its explanationPaCO2 (28‑32 mmHg) and bicarbonate; pH near normal
Vessels, open its explanationSystemic vascular resistance (SVR)
Clotting, open its explanationFactors XI and XIII, and protein S, fall
Plasma proteins, open its explanationAlbumin, total protein, plasma cholinesterase, modestly

What pregnancy leaves alone

SystemUnchanged
Lung mechanics, open its explanationCompliance does not fall; resistance does not rise
Blood pressure, open its explanationSame or slightly lower
Clotting, open its explanationFactors II and V
Liver, open its explanationLiver blood flow, about the same
Suxamethonium, open its explanationUsual dose despite lower cholinesterase

Heart and airway findings

FindingVerdict
Accentuated split S1, S3, systolic ejection murmur, open its explanationNormal in pregnancy
Diastolic murmur, open its explanationAbnormal: never explained by pregnancy
Breast enlargement; vascular, swollen airway mucosa, open its explanationNormal changes that make laryngoscopy hard

Metabolic and gut findings

FindingVerdict
Gastric emptying after delivery, open its explanationNormal within about a day; aspiration‑prone until then
Insulin resistance, open its explanationNormal, hormonal: placental lactogen, progesterone, oestrogen, cortisol
Ketosis during fasting labour, open its explanationExpected; harmless without diabetes, settles with carbohydrate
Routine intravenous fluids for that ketosis, open its explanationNot needed
Thromboxane, cyclo‑oxygenase‑1 (COX‑1) product, open its explanationAggregates platelets, constricts; never dilates or raises uterine flow

Sources: AHA/ACC 2024 · §6.3

Report a problem with card 9: Normal pregnancy or not

The fetal heart trace

10 / 21

Early decelerations are benign; late ones or a lost rate: check the mother, call the obstetrician.

The trace around a labour epidural

TraceAction
Early decelerations mirroring contractions, open its explanationBenign head compression: confirm comfort, continue routine care
Abnormal trace before epidural insertion, open its explanationInvolve the obstetrician first
Late decelerations after epidural bolus, open its explanationRecheck maternal vital signs, treat hypotension, summon obstetrician

Warning of uterine rupture

SignReliability
Fetal trace abnormality, especially bradycardia, open its explanationMost dependable warning
Maternal pain, open its explanationUnreliable; trust the fetal trace

Report a problem with card 10: The fetal heart trace

The hypertensive disorders

11 / 21

Pressure 160/110 or any other severe feature makes pre-eclampsia severe; haemolysis, elevated liver enzymes and low platelets (HELLP) by its labs; delivery cures.

Naming the disorder

FindingDiagnosis
New hypertension after 20 weeks, with proteinuria, open its explanationPre‑eclampsia
Pre‑eclampsia plus any one severe feature, open its explanationSevere pre‑eclampsia
Haemolysis, raised transaminases, low platelets in pre‑eclampsia, open its explanationHELLP syndrome

Severe features of pre-eclampsia (ACOG, as listed in Faust)

Feature (any one)Severe when
Blood pressure, two readings ideally 4 hours apart, open its explanationSystolic ≥160 or diastolic ≥110 mmHg
Platelets, open its explanationBelow 100,000 per microlitre
Liver, open its explanationEnzymes over twice normal; severe right‑upper‑quadrant or epigastric pain
Kidney, open its explanationCreatinine above 1.1 mg/dL, or doubled
Lungs, open its explanationPulmonary oedema
Brain and eyes, open its explanationNew headache, unexplained and unrelieved by analgesia; visual disturbance
Proteinuria (amount), open its explanationNot a severe feature; pre‑eclampsia can be diagnosed without it

Circulation in severe pre-eclampsia

MeasureChange
Systemic vascular resistance, open its explanationRaised: the dependable change; cardiac output varies
Intravascular volume, open its explanationContracted, not expanded

Treatment

SituationAction
Pre‑eclampsia, definitive treatment, open its explanationDeliver fetus and placenta: the only cure
Preterm pre‑eclampsia, open its explanationAntihypertensives buy time before delivery

Report a problem with card 11: The hypertensive disorders

Placenta accreta spectrum

12 / 21

Accreta adheres, increta invades, percreta perforates; each prior caesarean scar with previa raises the risk.

Nerve injury after delivery

13 / 21

Map the deficit to the nerve; a long second stage, not the epidural, usually causes it.

Part 3 · SituationsWhat now5 cards · about 3 min

  1. 14Magnesium and eclampsia
  2. 15Hypotension in the parturient
  3. 16The airway fails at caesarean
  4. 17Sudden collapse
  5. 18After delivery

Magnesium and eclampsia

14 / 21

Magnesium prevents and treats fits, drops pressure and reflexes, potentiates relaxants; calcium reverses toxicity.

Treating fits and toxicity

SituationAction
Seizure despite magnesium infusion, open its explanationExtra 1‑2 g magnesium bolus, then plasma level; not benzodiazepine
Suspected magnesium toxicity, open its explanationStop infusion; give IV calcium slowly
Excess magnesium after calcium given, open its explanationForced diuresis; dialysis if life‑threatening

What the infusion does

MeasureEffect
Blood pressure, open its explanationFalls: hypotension expected
Reflexes, breathing, bladder, open its explanationHyporeflexia, depressed breathing, urinary retention; not hyperreflexia or diuresis
Non‑depolarising relaxants, open its explanationIncreased sensitivity: smaller doses, monitor before extubation
Plasma magnesium on sulfate infusion, open its explanationTherapeutic 4–8 mEq/L; normal 1.5–2

Report a problem with card 14: Magnesium and eclampsia

Hypotension in the parturient

15 / 21

Displace the uterus, give phenylephrine unless the heart is slow; look for the cause.

The airway fails at caesarean

16 / 21

Oxygenate first, in six steps: better look, supraglottic airway, wake or proceed; nothing oxygenates: front-of-neck access.

1First laryngoscopy fails

FindingAction
Oxygenation intact, open its explanationMost experienced anaesthetist; adjust position, cricoid, equipment; retry once

2Intubation fails

FindingAction
Retry fails: failed intubation, open its explanationOxygen, call for help, second‑generation supraglottic device

3Oxygenating through the supraglottic device

SurgeryAction
Elective, open its explanationWake her
Urgent, open its explanationProceed on the device; intubate through it only if essential

4Cannot intubate, cannot oxygenate (CICO)

FindingAction
Supraglottic device and facemask both fail, open its explanationDeclare CICO; call ear, nose and throat surgeon or intensivist

5Front-of-neck access

FindingAction
CICO declared, open its explanationScalpel‑bougie‑tube; small cannulas fail more, especially in obesity

6After front-of-neck access

FindingAction
Oxygenation restored, open its explanationReview wake or proceed against maternal and fetal compromise
Oxygenation not restored, open its explanationCardiac arrest protocol; caesarean delivery beyond 20 weeks

Report a problem with card 16: The airway fails at caesarean

Sudden collapse

17 / 21

Collapse in labour or just after birth is embolism until proven otherwise; name which.

Amniotic fluid embolism: diagnostic criteria (Miller)

CriterionNeeded
Sudden cardiorespiratory compromise, open its explanationYes
Disseminated intravascular coagulation (DIC), open its explanationDocumented
Onset, open its explanationIn labour or within 30 minutes of placental delivery
Another obvious diagnosis, open its explanationNone
Diagnosis, open its explanationAll four met: amniotic fluid embolism, by exclusion

Which embolism

PresentationDiagnosis
Sudden hypoxia, hypotension, then coagulopathic bleeding in labour, open its explanationAmniotic fluid embolism
Seizure or bronchospasm in amniotic fluid embolism, open its explanationSeizures in about half; bronchospasm rare, under 15%
Amniotic fluid embolism: commonest symptom, commonest sign, open its explanationSymptom dyspnoea; signs hypotension and fetal distress
Amniotic fluid embolism after second‑trimester termination, open its explanationCan occur; a diagnosis of exclusion
Collapse minutes after amniotomy, even with heavy bleeding, open its explanationAmniotic fluid embolism until proven otherwise
Postpartum CT pulmonary angiography filling defect, open its explanationThrombotic pulmonary embolism; amniotic fluid embolism has no imaging sign

Confirming pulmonary embolism

SuspicionConfirmatory test
Suspected embolism with leg thrombosis signs, open its explanationCompression duplex ultrasound first
Suspected embolism, no leg signs, open its explanationVentilation‑perfusion (V/Q) scan; computed tomography pulmonary angiography (CTPA) if X‑ray abnormal

Report a problem with card 17: Sudden collapse

After delivery

18 / 21

After delivery, look past the block: fever is infection until proven; itch after morphine takes nalbuphine.

Fever after delivery

PresentationPresume first
Postpartum headache with fever, neck stiffness, drowsiness, open its explanationMeningitis until proven otherwise, not dural puncture headache
Fever, leukocytosis, back pain days after neuraxial block, open its explanationEpidural abscess until proved otherwise: urgent spinal MRI first

Problems during the block

ProblemAction
Falling urine output in labour with catheter, open its explanationCheck and clear blocked catheter before blaming epidural
Itch after neuraxial morphine, open its explanationNalbuphine (mixed opioid agonist–antagonist); pain relief largely kept

Report a problem with card 18: After delivery

Part 4 · Conditions and mechanismsWhy it is true2 cards · about 1 min

  1. 19Pulmonary hypertension and peripartum cardiomyopathy
  2. 20Risk factors and Zika

Pulmonary hypertension and peripartum cardiomyopathy

19 / 21

Protect the right heart in pulmonary hypertension; name peripartum cardiomyopathy by its echo and timing.

Pulmonary hypertension

GoalHow
Prevent a rise in pulmonary vascular resistance (PVR), open its explanationAvoid hypoxaemia, acidosis, hypercarbia, hypothermia, pain

Peripartum cardiomyopathy: diagnostic criteria (Stoelting, StatPearls)

CriterionNeeded
Heart failure, open its explanationNew, around delivery
Timing, by source, open its explanationStoelting: around delivery; Barash: late pregnancy to 6 weeks
Other cause or earlier heart disease, open its explanationNone
Echo, open its explanationLeft ventricular ejection fraction (LVEF) under 45% or fractional shortening under 30%
Diagnosis, open its explanationEvery criterion above met

Report a problem with card 19: Pulmonary hypertension and peripartum cardiomyopathy

Risk factors and Zika

20 / 21

Plain facts: Zika means microcephaly; endometriosis follows early menarche, pre-eclampsia nulliparity and obesity.

Risk factors

ConditionRisk factor
Endometriosis (dysmenorrhoea, dyspareunia, pelvic pain), open its explanationEarly menarche: modest but real risk factor
Pre‑eclampsia, open its explanationObesity or nulliparity; age extremes; smoking lowers risk

Infection in pregnancy

ExposureFetal effect
Zika exposure in pregnancy, open its explanationMicrocephaly, not macrocephaly, skeletal dysplasia or cardiopulmonary defect

Report a problem with card 20: Risk factors and Zika

TrapsCheck these before you finish1 card · about 1 min

  1. 21Traps

Traps

21 / 21

The tempting choice is the familiar one; the books often name another.

Clinical situationRight call, not the tempting one
Peroneal palsy for foot drop after long labour, open its explanationLumbosacral trunk compression by fetal head, not epidural
Local anaesthetic itself raises uterine flow, open its explanationFalling sympathetic tone raises uterine flow; hypotension lowers it
Suxamethonium crosses the placenta, open its explanationSmall lipid‑soluble poorly ionised drugs cross; neuromuscular blockers barely do
Asthma with pre‑eclampsia: ergot once carboprost excluded, open its explanationOxytocin; carboprost barred by asthma, ergot by pre‑eclampsia
Diastolic murmur as normal in pregnancy, open its explanationAbnormal; normal is systolic ejection murmur, else accentuated S1
Ephedrine for spinal hypotension at caesarean, open its explanationPhenylephrine preferred unless bradycardic; ephedrine acceptable, not first
More clear fluid once haemoglobin has fallen, open its explanationRed cells plus plasma en route to theatre
Rapid intravenous methylergometrine bolus, open its explanationGive 0.2 mg IM; slow monitored IV only last resort
Wheeze as the sign of amniotic fluid embolism, open its explanationRare, under 15%; collapse, hypoxia, coagulopathy dominate
Smoking as pre‑eclampsia risk factor, open its explanationLowers risk (Stoelting, Barash); Faust lists it: dissent
Amniotic fluid embolism with CT filling defect, open its explanationThrombotic pulmonary embolism; amniotic fluid embolism diagnosed by exclusion
Midazolam for seizure on magnesium, open its explanationFurther 1–2 g magnesium bolus, then check plasma level
Bladder dysfunction after long low‑dose epidural, open its explanationProlonged second stage, pelvic floor; not epidural or catheter

Report a problem with card 21: Traps

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QuizCheck yourself21 practice scenariosAnswers checked against the books and guidelines.

Sheet 05 · Obstetric21 / 21

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